Objective To explore the clinical manifestations, diagnosis, transnasal endoscopic surgical treatment and prognosis of craniocerebral complications caused by invasive fungal sinusitis.Methods Clinical data of 3 cases suffered from craniocerebral complications caused by IFRS(invasive fungal rhino-sinusitis,IFRS) were reported, including cerebral abscess of frontal lobe(1 case), meningitis(1 case) and cavernous sinus thrombophlebitis(1 case), and relevant literature reports were summarized.Results All 3 patients in this group underwent transnasal endoscopic surgery, which were pathologically confirmed as mucor mycosis infection. All patients were cured after standard antifungal therapy, regular nasal endoscopic debridement, local dressing change, deep-sea saline irrigation and other treatments in collaboration with the neurology department.Conclusions Craniocerebral complications caused by IFRS were rare, easy to be missed and misdiagnosed. The treatment of the disease is very difficult. Transnasal endoscopic surgery combined with systemic antifungal therapy may be an effective treatment strategy.