Objective To analyze the relationship between tissue eosinophils and serum specific immunoglobulin E (sIgE) in patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP) and their clinical characteristics.Methods A total of 192 patients with CRSwNP undergoing functional endoscopic sinus surgery from June 2019 to June 2021 were selected and divided into sIgE-positive group and sIgE-negative group based on the results of serum sIgE monitoring. The preoperative visual analogue scale (VAS) score, tissue eosinophil count, Lund-Mackay score, and Lund-Kennedy score were compared between the two groups.Results The differences of gender, age between the two groups were statistically insignificant (P＞0.05). There was no statistical difference between the number of cases with positive sIgE and eosinophils infiltration (P＞0.05). In terms of clinical characteristics, there were significant differences in preoperative VAS score, Lund-Mackay score and Lund-Kennedy score between sIgE-positive with eosinophils infiltration group and the other three groups.Conclusions There is no definite correlation between the infiltration degree of eosinophil and allergic reaction in patients with CRSwNP. The subjective and objective symptoms were aggravated in CRSwNP patients when eosinophils infiltration coexisted with positive sIgE.