Objective To analyze the long term clinical outcomes of vertical partial laryngectomy (VPL) in management of patients with glottic carcinoma, and to explore potential prognostic factors on survival outcomes.Methods Clinical data of 548 glottic carcinoma patients underwent VPL in our department from Jan 2005 to Dec 2010 were retrospectively studied. The long-term clinical outcomes including overall survival (OS) and disease free survival (DFS) were evaluated. Cox regression models were used to analyze the factors impacting the prognosis.Results Of all cases, 537 (98.0%) were male and 11 (2.0%) were female, with an average age of (59.0±9.4)years (range: 34 to 89 years). As for the T stage, 169 patients (30.8%) were at T1, 316 (57.7%) at T2, 63 (11.5%) at T3 of glottic carcinoma. The 3-, 5-and 10-year OS rates were 96.5%，92.1% and 83.3%, respectively. And the 3-, 5- and 10-year DFS rates were 93.2%，88.0% and 79.6%, respectively. Patients with advanced T stage and greater tumor area experienced inferior survival outcomes (P<0.001). Regarding patients with the same T stage of T2 or T3, those with greater tumor area had poorer survival outcomes (P<0.05). Cox regression model analyses revealed that T stage and area of tumor as well as patient’s age were predictive factors for the prognosis of glottic carcinoma.Conclusions With excellent survival outcome, VPL is a reliable procedure and may be considered for T1-T2 and selected T3 glottic carcinoma patients with poor larynx exposure. Advanced T stage, greater tumor area and age older than 70 years are risk factors of survival in patients with glottic carcinoma.