环境内分泌干扰物在变应性鼻炎发病机制中的作用研究
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Role of the pathogenesis of allergic rhinitis caused by environmental endocrine disrupting chemicals
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    摘要:

    变应性鼻炎(AR)的发病率逐年上升,其发病与环境因素密不可分,其中,环境内分泌干扰物(EDCs)是一类可干扰内源性激素的典型环境污染物,流行病学研究显示AR发病与EDCs暴露有一定的关联性。EDCs在AR发病机制中的作用已有探索性研究,EDCs可通过作用于激素信号通路,促进氧化应激和气道炎症,打破辅助型T细胞(Th)1/Th2平衡,引起微生物群失调,调控表观遗传调控等途径引起呼吸道变应性炎性反应,说明EDCs暴露可能是诱发AR的一个重要因素。本文就EDCs来源、分类、污染现状、特性及对AR发病的影响和可能的作用机制进行综述。

    Abstract:

    The incidence of allergic rhinitis (AR) is increasing year by year, which is closely related to environmental factors. Among them, environmental endocrine disrupting chemicals (EDCs) are typical environmental pollutants, which can interfere with endogenous hormones. Epidemiological studies have shown that there is a certain correlation between the incidence of AR and EDCs exposure. The role of EDCs in the pathogenesis of AR has been explored. EDCs can promote oxidative stress and airway inflammation by acting on hormone signaling pathways, break the balance of Th1(Thelper cell 1)/Th2(Thelper cell 2), cause microbiota imbalance, regulate epigenetic regulation and other pathways to cause respiratory allergic inflammatory response. The EDCs exposure may be an important factor in inducing AR. In this paper, it will be reviewed for the source, classification, pollution status, characteristics and possible mechanism of EDCs about AR.

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    [1] 曹玉洁, 李正埼, 周纯, 等. 变应性鼻炎特异性病毒应答相关基因的生物信息学分析[J]. 中国耳鼻咽喉颅底外科杂志, 2022, 28(1):43-50.
    [2] Casas M, Gascon M. Prenatal exposure to endocrine-disrupting chemicals and asthma and allergic diseases[J]. J Investig Allergol Clin Immunol, 2020, 30(4):215-228.
    [3] Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endocrine-disrupting chemicals:an endocrine society scientific statement[J]. Endocr Rev, 2009, 30(4):293-342.
    [4] Fu X, Xu J, Zhang R, et al. The association between environmental endocrine disruptors and cardiovascular diseases:A systematic review and meta-analysis[J]. Environ Res, 2020, 187:109464.
    [5] Gore AC, Chappell VA, Fenton SE, et al. EDC-2:the endocrine society's second scientific statement on endocrine-disrupting chemicals[J]. Endocr Rev, 2015, 36(6):1-150.
    [6] Haug LS, Sakhi AK, Cequier E, et al. In-utero and childhood chemical exposome in six European mother-child cohorts[J]. Environ Int, 2018, 121(Pt 1):751-763.
    [7] Murawski A, Tschersich C, Rucic E, et al. Parabens in urine of children and adolescents in Germany-human biomonitoring results of the german environmental survey 2014-2017(GerES V)[J]. Environ Res, 2021, 194:110502.
    [8] Monneret C. What is an endocrine disruptor?[J]. C R Biol, 2017, 340(9-10):403-405.
    [9] Paciência I, Cavaleiro Rufo J, Silva D, et al. Exposure to indoor endocrine-disrupting chemicals and childhood asthma and obesity[J]. Allergy, 2019, 74(7):1277-1291.
    [10] Shi W, Lin Z, Liao C, et al. Urinary phthalate metabolites in relation to childhood asthmatic and allergic symptoms in Shanghai[J]. Environ Int, 2018, 121(Pt 1):276-286.
    [11] Bølling AK, Sripada K, Becher R, et al. Phthalate exposure and allergic diseases:Review of epidemiological and experimental evidence[J]. Environ Int, 2020, 139:105706.
    [12] Hwang M, Choi K, Park C. Urinary levels of phthalate, bisphenol, and paraben and allergic outcomes in children:korean national environmental health survey 2015-2017[J]. Sci Total Environ, 2022, 818:151703.
    [13] Clayton EM, Todd M, Dowd JB, et al. The impact of bisphenol A and triclosan on immune parameters in the U.S. population, NHANES 2003-2006[J]. Environ Health Perspect, 2011, 119(3):390-396.
    [14] Hoppin JA, Jaramillo R, London SJ, et al. Phthalate exposure and allergy in the U.S. population:results from NHANES 2005-2006[J]. Environ Health Perspect, 2013, 121(10):1129-1134.
    [15] Segner H, Verburg-van Kemenade B, Chadzinska M. The immunomodulatory role of the hypothalamus-pituitary-gonad axis:Proximate mechanism for reproduction-immune trade offs?[J]. Dev Comp Immunol, 2017, 66:43-60.
    [16] Chalubinski M, Kowalski ML. Endocrine disrupters——potential modulators of the immune system and allergic response[J]. Allergy, 2006, 61(11):1326-1335.
    [17] Cai Y, Zhou J, Webb DC. Estrogen stimulates Th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthma[J]. Int Arch Allergy Immunol, 2012, 158(3):252-260.
    [18] Rogers JA, Metz L, Yong VW. Review:Endocrine disrupting chemicals and immune responses:a focus on bisphenol-A and its potential mechanisms[J]. Mol Immunol, 2013, 53(4):421-430.
    [19] Peinado FM, Artacho-Cordón F, Barrios-Rodríguez R, et al. Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies[J]. Environ Res, 2020, 186:109561.
    [20] Liu Z, Lu Y, Zhong K, et al. The associations between endocrine disrupting chemicals and markers of inflammation and immune responses:A systematic review and meta-analysis[J]. Ecotoxicol Environ Saf, 2022, 234:113382.
    [21] Cimmino I, Oriente F, D'Esposito V, et al. Low-dose Bisphenol-A regulates inflammatory cytokines through GPR30 in mammary adipose cells[J]. J Mol Endocrinol, 2019, 63(4):273-283.
    [22] Karunarathne W, Molagoda I, Choi YH, et al. Bisphenol A:A potential Toll-like receptor 4/myeloid differentiation factor 2 complex agonist[J]. Environ Pollut, 2021, 278:116829.
    [23] Mohammadi H, Ashari S. Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways[J]. Environ Sci Pollut Res Int, 2021, 28(27):35488-35527.
    [24] Han M, Lee D, Lee SH, et al. Oxidative stress and antioxidant pathway in allergic rhinitis[J]. Antioxidants (Basel), 2021, 10(8):1266.
    [25] You H, Chen S, Mao L, et al. The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma[J]. Food Chem Toxicol, 2014, 71:272-281.
    [26] Kuo CH, Hsieh CC, Kuo HF, et al. Phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation[J]. Allergy, 2013, 68(7):870-879.
    [27] Guo H, Liu T, Uemura Y, et al. Bisphenol A in combination with TNF-alpha selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity[J]. Cell Mol Immunol, 2010, 7(3):227-234.
    [28] Wu M, Wang S, Weng Q, et al. Prenatal and postnatal exposure to bisphenol A and asthma:a systemic review and meta-analysis[J]. J Thorac Dis, 2021, 13(3):1684-1696.
    [29] Goto M, Takano-Ishikawa Y, Ono H, et al. Orally administered bisphenol A disturbed antigen specific immunoresponses in the naïve condition[J]. Biosci Biotechnol Biochem, 2007, 71(9):2136-2143.
    [30] Belkaid Y, Hand TW. Role of the microbiota in immunity and inflammation[J]. Cell, 2014, 157(1):121-141.
    [31] Corrêa-Oliveira R, Fachi JL, Vieira A, et al. Regulation of immune cell function by short-chain fatty acids[J]. Clin Transl Immunology, 2016, 5(4):e73.
    [32] Maddalon A, Galbiati V, Colosio C, et al. Glyphosate-based herbicides:Evidence of immune-endocrine alteration[J]. Toxicology, 2021, 459:152851.
    [33] Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota:a major player in the toxicity of environmental pollutants?[J]. NPJ Biofilms Microbiomes, 2016, 2:16003.
    [34] Baccarelli A, Bollati V. Epigenetics and environmental chemicals[J]. Curr Opin Pediatr, 2009, 21(2):243-251.
    [35] Wang IJ, Karmaus WJ, Chen SL, et al. Effects of phthalate exposure on asthma may be mediated through alterations in DNA methylation[J]. Clin Epigenetics, 2015, 7(1):27.
    [36] Yang CF, Karmaus W, Yang CC, et al. Bisphenol a exposure, DNA methylation, and asthma in children[J]. Int J Environ Res Public Health, 2020, 17(1):298.
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引用本文

孔江维,李雨琦,刘小涵,张小兵.环境内分泌干扰物在变应性鼻炎发病机制中的作用研究[J].中国耳鼻咽喉颅底外科杂志,2023,29(5):109-113

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  • 收稿日期:2022-10-12
  • 在线发布日期: 2023-10-31
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