Objective To discuss the effect of endoscopic surgery on orbital apex schwannoma and the strategy of intraoperative neuroprotection. Methods Retrospective analysis on data of 9 patients suffering orbital apex schwannoma diagnosed and undergone endoscopic surgery in our hospital from May 2015 to June 2022. Image navigation system was used to assist all operations. The oculomotor nerve was monitored by nerve electrophysiology monitoring technique during the operation. Descriptive statistical analysis method was adopted to include demographic information, surgical data, prognostic data, etc. Results Through post-operation follow-up for 10 to 95 months, 8 of the 9 patients were applied total resection and 1 was subtotal resection. The preoperative symptoms of all patients were relieved or improved to different degrees. There were no surgical complications such as death or intracranial infection. None of the 9 patients had occurred any relevant nerve injury during operation or neurological dysfunction after operation. Conclusion Endoscopic surgical resection of orbital apex schwannoma is safe and effective. By Combining the application of image navigation system and nerve electrophysiology monitoring technology, it has had the advantages of high total resection rate, less trauma, fewer complications and preservation of neurological function.