Objective To investigate the therapeutic effectiveness of sound stimulation combined with cognitive behavior therapy (CBT) on chronic tinnitus.Methods A total of 49 patients with chronic tinnitus were randomly divided into intervention group (n=25) and control group (n=24),. All the patients underwent sound stimulation for one month, and those in the intervention group also received personalized CBT for one month, while the patients from control group did not receive such treatment. Additionally, all patients were required to fill out the questionnaires including tinnitus handicap inventory (THI), self-rating anxiety scale (SAS),and Pittsburgh sleep quality index (PSQI) before treatment and 30 days of treatment.Results All the 49 cases completed the trial. The follow-up after one month of treatment revealed that the mean values of THI, SAS and PSQI were decreased by 15.58, 15.46 and 4.96 in the control group, and 40.52, 41.76 and 7.72 in the intervention group, respectively. The differences of decreases in THI, PSQI and SAS between the two groups were statistically significant (P < 0.05). After intervention, the THI, PSQI and SAS scores of the intervention group were significantly lower than those of the control group.Conclusion Both sound stimulation and CBT can predict the therapeutic effect, and the therapeutic effect of sound stimulation combined with CBT is superior to sound stimulation alone. Gender, age and the hearing impairment are the most relevant risk factors for tinnitus.