Objective To investigate the correlation between glomerular filtration rate (GFR) and sudden deafness, and to analyze the prognostic factors of sudden deafness.Methods Clinical data of 261 patients suffering from sudden deafness who were hospitalized in our department from Jan 2021 to Oct 2022 were retrospectively analyzed, and the estimate glomerular filtration rate (eGFR) levels of the patients with different clinical characteristics were compared. The influencing factors for the prognosis of sudden deafness were analyzed and the receiver operating characteristic curve was drawn to evaluate the predictive efficiency.Results ①Hearing values (dB) of patients with sudden deafness were linearly and negatively correlated with eGFR levels (P=0.02). ②The level of eGFR was associated with gender, age, hypertension, diabetes, smoking and type of hearing loss of patients with sudden deafness (all P＜0.05). ③The eGFR level and hearing loss type were independent influencing factors for the prognosis of sudden deafness (P＜0.05). ④The area under the receiver operating characteristic curve of eGFR was 0.704 (95%CI:0.642~0.766), and the prediction model was statistically significant (P＜0.001). When the Youden index was 0.360, the optimal decision threshold was 103.50 mL·min^-1·1.73 m^-2.Conclusions ①The level of eGFR is related to the patient’s gender, age, history of hypertension, history of diabetes, history of smoking and type of hearing loss. ②The level of eGFR and type of hearing loss are independent factors influencing the prognosis of sudden deafness.