Objective To explore the clinical characteristics and treatment methods of aspirin intolerance triad (AIT), summarize the cutting-edge research at home and abroad, and summarize the latest diagnosis and treatment experience.Methods A retrospective study was conducted to analyze the medication characteristics, clinical features, sinus CT, nasal endoscopy, history of nasal and sinus surgery, and treatment status of 14 AIT patients. Relevant literature was reviewed.Results One of 14 patients had an acute attack of asthma, and the operation was postponed after preoperative evaluation;11 cases of 14 patients were followed up for 6 months without recurrence, and the condition was basically under control; 2 patients of 14 patients had recurrent nasal symptoms, one of them underwent surgery again, and the other one continued drug combination therapy.Conclusions Due to its accompanying asthma and related drug allergies, AIT has severe symptoms of sinusitis, which is mostly a complete group of sinusitis, prone to recurrence, long-term loss of smell, and early clinical misdiagnosis.The key to the treatment of this disease is to have a clear diagnosis in the early stage, standardize medication during the perioperative period, thoroughly remove the lesion in the early stage, and provide regular postoperative medication treatment.