Objective To analyze the status of anxiety and depression and its influencing factors in patients with olfactory dysfunction after omicron variant infection to lay a theoretical foundation for formulating effective psychological intervention measures.Methods A online questionnaire-based survey was conducted from December 2022 to January 2023 during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Chongqing. The psychological assessment included generalized anxiety disorder scale (GAD-7) for anxiety symptoms, the patient health questionnaire (PHQ-9) for depressive symptoms, and visual analogue scale (VAS) for olfactory function. Chi-square test and multivariate logistic regression were used to analyze the status of anxiety and depression and its influencing factors. Results A total of 367 patients were collected, including 182 patients with olfactory dysfunction and 185 patients without olfactory dysfunction. The detection rates of anxiety and depression in patients with olfactory dysfunction were 46.7% and 63.2% respectively, both higher than those without olfactory dysfunction. Multivariate logistic regression showed that the patients with long duration of olfactory decline(OR=1.660) and high VAS scores of olfactory function (OR=8.993) had a higher risk of anxiety. Female (OR=2.964) and high VAS scores of olfactory function (OR=4.423) were risk factors for depression.Conclusions There is a certain degree of depression and anxiety among patients with SARS-CoV-2 infection. Patients with olfactory dysfunction have a higher detection rate of anxiety and depression. Psychological counseling and humanistic care should be strengthened to improve and promote their psychological health.