肠道微生物菌群对变应性鼻炎的影响
作者:
作者单位:

作者简介:

通讯作者:

基金项目:

国家自然科学基金(82171119, 82171120);山西省自然科学基金项目(201901D111386);山西省卫生健康委员会应用研究 项目(20200076)。


Effect of intestinal microbiota on allergic rhinitis
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    变应性鼻炎(AR)主要是由免疫球蛋白E(IgE)介导的多种免疫细胞及细胞因子参与的I型变态反应。目前AR的患病率呈逐年上升的趋势,临床治疗中存在诸多问题,其发病机制有待进一步的研究。近年来,随着对肠道菌群研究的深入,人们发现肠道菌群及其代谢物可通过神经、免疫及内分泌通路与多个器官发生交互作用,如通过调节免疫系统进而影响哮喘、AR等变应性疾病,因此肠道菌群紊乱或许是AR发病的机制之一。故本文将从肠道菌群、肠道菌群对免疫系统的影响、肠道菌群与AR的关系以及应用益生菌、益生元、细菌裂解产物改善菌群失调治疗AR的相关研究进行综述,为治疗AR提供新的参考依据。

    Abstract:

    Allergic rhinitis(AR) is a type I allergic reaction mainly mediated by immunoglobulin E(IgE),which is involved in various immune cells and cytokines. At present, the prevalence of AR is increasing year by year. There are many problems in clinical treatment, and its pathogenesis needs further study. Recently, the in-depth study of intestinal microbiota found that intestinal microbiota and its metabolites could interact with multiple organs through neural, immune and endocrine pathways.For example, the regulation of the immune system affected asthma, AR and other allergic diseases.Therefore, intestinal microbiota disorders may be one of the mechanisms of the pathogenesis of AR. In this paper, we reviewed intestinal microbiota, the impact of intestinal microbiota on immune system, the relationship between intestinal microbiota and AR, as well as the application of probiotics, prebiotics and bacterial lysates. It will provide a new reference for the treatment of AR.

    参考文献
    相似文献
    引证文献
引用本文

马永利,安云芳,韩兰,赵长青.肠道微生物菌群对变应性鼻炎的影响[J].中国耳鼻咽喉颅底外科杂志,2024,30(3):109-115

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:2023-05-25
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2024-07-03
温馨提示

本刊唯一投稿网址:www.xyosbs.com
唯一办公邮箱:xyent@126.com
编辑部联系电话:0731-84327210,84327469
本刊从未委托任何单位、个人及其他网站代理征稿及办理其他业务联系,谨防上当受骗!

关闭