Neuroimmune research focuses on the interaction mechanisms between the nervous system (including the central cortex and related nuclei) and the immune system (including various immune cells), involving at least both peripheral and peripheral and central levels. The concept of nose brain axis was proposed based on the research results of rhinology and other disciplines. This concept focuses on how peripheral inflammation affects the central nervous system (CNS), how the CNS regulates peripheral inflammation, and the mechanisms by which the two interact. The effects of allergic rhinitis (AR) on CNS have been paid more attention, but the mechanisms remain unclear. On the other hand, little attention has been paid to the effects of CNS on AR, and the mechanisms are rarely explored. Understanding the neuroimmune mechanisms of the interaction between AR and CNS is conducive to re-understanding the pathogenesis of AR and providing new therapeutic ideas and methods for clinical treatment.