Cleft palate is the most common congenital oral and maxillofacial deformity. The incidence of cleft palate is high, which seriously affects the hearing and speech function of children. Children with cleft palate often lead to otitis media with effusion(OME). The pathogenesis of children with cleft palate is mainly due to the soft palate muscle tissue defects resulting in eustachian tube dysfunction, OME can affect the hearing of children, and further lead to speech disorders. However, there is no consensus on the treatment mode and timing of cleft palate children with OME. The main treatment of this disease is individualized according to the severity of the child’s condition. Current treatment methods mainly include conservative treatment, Ventilation tube insertion (VTI) and other treatments. This paper reviews the treatment of cleft palate with OME in children in recent years, which mainly includes the treatment timing, characteristics, complications and prognosis of VTI. It will provide some constructive advice for the treatment of this disease.