皮质类固醇激素药物洗脱支架治疗CRSwNP研究进展
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山西医科大学,山西医科大学附属第一医院

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Research progress of corticosteroid drug-eluting stent in the treatment of CRSwNP
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    摘要:

    皮质类固醇激素是慢性鼻窦炎伴鼻息肉(CRSwNP)术后最常用的药物治疗。虽然局部使用皮质类固醇可有效减轻与CRS相关的症状,且减少全身副作用,但其在鼻腔内的分布是有限的,主要依赖于其释放介质。皮质类固醇药物洗脱支架是一种相对新颖的技术,可以将高浓度的皮质类固醇直接且持续的释放至鼻窦黏膜上。本文综述了两种类固醇药物洗脱支架的临床疗效及安全性证据。目前,用于慢性鼻窦炎的药物支架最常用于内窥镜鼻窦手术的术中和术后,可显著改善黏膜炎症及术后症状,并降低鼻息肉的复发。综合临床疗效,药物支架结合其它局部给药方式可以给予更好的药物分布,为术中及术后联合用药提供思路。

    Abstract:

    Corticosteroids are the most used drug therapy for chronic rhinosinusitis with nasal polyps (CRSwNP) after surgery. While topical corticosteroids effectively reduce the symptom associated with CRS and systemic side effect, their distribution inside the nasal cavity is limited and primarily dependent on their bearing medium. Corticosteroid-eluting implants serve as relatively novel technology, allowing targeted, sustained release of a high concentration of corticosteroids directly onto the sinus mucosa. This article reviews the clinical efficacy and safety evidence of two drug-eluting implants. At present, drug implant for CRS are most used during or after operation, which are beneficial to improve mucosal inflammation burden and postoperative symptoms, and reduce the recurrence of nasal polyps. Combining clinical effect, drug implants with other topical drug administration can give better drug distribution, which provides ideas for intraoperative and postoperative combined drug use.

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  • 收稿日期:2024-04-12
  • 最后修改日期:2024-05-10
  • 录用日期:2024-05-13
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