[Abstract] Objective: To investigate the clinical features of patients with deep cervical multispace abscess and to preliminarily analyze the therapeutic effect of drainage through the natural communication channels between the anatomical spaces. Methods: The clinical data of 17 patients with deep cervical multispace abscess were retrospectively analyzed. After a definite diagnosis was made, all patients underwent open drainage surgery. During the operation, a semi-tube drain was placed through the natural communication channels between the anatomical spaces of the neck. The surgical incision was opened, and anti-infection and systemic supportive treatments were strengthened. The drain was removed after the secretion in the surgical area disappeared, and the wound was closed in a second phase after healthy granulation tissue grew. Results: Among the 17 patients, 13 were male (76.5%) and 4 were female (23.5); the age ranged from 28 to 76 years (mean age was 56.3 years). The causes of the disease were: dental infection in 9 patients (52.9%), a history of foreign body in the pharynx in 3 patients (17.7%), and the source of infection could not be determined in 5 patients (29.4%). The abscess was located in the supraglossal area in 15 patients (88.2%), and 5 patients (29.4%) had an abscess in both the supraglossal and infraglossal areas. The abscess involved the submental space in 16 patients (94.1%), the parapharyngeal space in 13 patients (76.5%), the parotid space in 2 patients (11.8%), the retropharyngeal space in 1 patient (5.9%), the temporomandibular space in 1 patient (5.9%), and the temporomandibular joint space in 1 patient (5.9%). The abscess extended through the cervical sheath to the anterior superior mediastinum in 2 patients (11.8%). In the bacterial smear, secretion culture results, a total of 8 patients grew bacteria, including 4 cases of Klebsiella pneumoniae pneumoniae, 1 case of Acinetobacter calcoaceticus, all of which were patients with diabetes; 2 cases of Streptococcus anginosus pharyngitis, and 1 case of Escherichia coli. Two cases of unknown Gram-positive coccus bacteria were found in the bacterial smear; no bacterial growth was seen in 7 cases. One patient with involvement of the parotid space underwent parotid abscess drainage operation and was cured. One patient had bleeding at the neck drainage site on the sixth postoperative day, with local compression not effective, and was cured by right external carotid artery embolization. One patient with a lower gastrointestinal tract tumor died of acute lower gastrointestinal hemorrhage during hospitalization. The other patients were discharged after recovery. The average time for removal of drainage tubes was 11 to 20 days, with an average of 16.3 days; the average length of stay was 11 to 49 days, with an average of 24.3 days. Conclusion: By opening the natural communication channels between the deep neck interspaces and allowing for adequate drainage while facilitating dressing changes and observation of infection control, multiple incision can be avoided. Combining sensitive antibiotics and nutritional support is an effective method for treating deep neck multispace abscess.