Abstract: Objective: To discuss the clinical features and treatment experience of Ki-mura’s disease and improve the diagnosis and treatment of this disease. Methods: A retrospective analysis was conducted on the clinical data of Hunan Provincial People's Hospital and Nanhua Hospital Affiliated to University of South China. From January 2006 to June 2024, the medical history, laboratory tests, imaging examinations, patho-logical data, treatment plans, and prognosis of 19 patients diagnosed with KD by pathological examination were collected. Relevant literatures were consulted through Pubmed to understand the latest progress in KD’s research. Results:1) Clinical fea-tures: Nineteen patients presented with head and neck mass, and some patients had combined mass in other areas, including axillary lymph node, subclavian lymph node, inguinal lymph node and upper arm mass.. 2) Auxiliary examinations showed an in-crease in the proportion or count of peripheral blood eosinophils in 13cases (68.4%, 13/19). Ultrasound examinations were performed in 19 patients, showing a low-echo or anechoic mass with clear boundaries. CT examinations were performed in 18 pa-tients, showing a uniform low-density mass with clear boundaries and uniform mild to moderate enhancement.3) Histopathological features: massive eosinophil infiltration, eosinophilic micro-abscess formation, lymphoid follicle hyperplasia, enlargement of interfollicular area, and follicular lysis.4) Prognosis：Eighteen patients underwent surgical treatment, and one patient received treatment with corticosteroids and cyclo-phosphamide. All 19 patients were followed up, with a follow-up ranging from 1 to 10 years. Six patients had a recurrence of a mass at the original incision site (31.6%, 6/19). Among them, 5 cases underwent reoperation, all cases were controlled, and one case received adjuvant radiotherapy with a total dose of 30 Gy, and there was no re-currence after a follow-up of 3 years. One patient showed a relief in the mass after 2 weeks of treatment with glucocorticoids and cyclophosphamide. The mass recurred 5 months after stopping the medication. Then the patient underwent a surgical treat-ment, there was no recurrence during a 4-year follow-up. None of the patients died due to recurrence. Conclusion: Kimura's disease is a Th2-type inflammatory disease characterized by increased peripheral blood eosinophils and elevated serum IgE lev-els, presenting as painless masses, most commonly in the head and neck region. The treatment mainly involves surgical intervention, but Kimura's disease has a tendency to recur postoperatively; adjuvant radiotherapy can help reduce recurrence. In patients with recurrence, corticosteroids and immunotherapy may be administered. Biologics targeting Th2-type inflammatory cytokines may offer breakthroughs in the treatment of Kimura's disease.