Objective To retrospectively analyze the clinical data of 4 patients with nasal cavity seromucinous hamartoma(SMH), which summarized the clinical and pathological characteristics of SMH.Methods There were 4 patients(3 males and 1 female). The four patients ranged from 23 to 66 years old,with an average age of 39.75 years old. The main symptoms of the 4 patients were unilateral nasal congestion and purulent discharge.Three lesions of the patients were located in the uncinate process,and one lesion in the middle turbinate.Pathological changes manifest was clustered or lobular proliferation of mucinous glands and ducts under the mucosa. Results All patients underwent endoscopic lesion resection, and the pathological diagnosis was SMH, manifest was clustered or lobular proliferation of mucinous glands and ducts under the mucosa. Immunohistochemical results:CK7 and CK19 are diffuse positive, while S100, p63 and EMA are focal positive. Followed up for 6 to 48 months, with no recurrence.Conclusions The clinical symptoms of nasal cavity SMH are lack of specificity, and the pathology of the SMH is unique. Surgical removal of the lesion is an effective treatment method.