Objective To investigate the clinical efficacy and safety of implanting fully degraded sinus drug stents in patients with chronic thinosinusitis and nasal polyps (CRSwNP) 2 weeks after functional endoscopic sinus surgery. Methods A total of 50 patients diagnosed in the Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College were were collected and randomly divided into 25 cases in the intraoperative implantation group and 25 cases in the postoperative implantation group. Patients in both groups underwent functional endoscopic sinus surgery for total sinus opening and nasal polypectomy. The intraoperative implantation group was taken as the control group. During the operation, a fully degradable sinus drug stent was randomly implanted in one side of the ethmoid sinus in the surgical cavity at the same time. The postoperative implantation group was taken as the experimental group. Two weeks after endoscopic sinus surgery, the nasal cavity was cleaned by nasal endoscopy under local anesthesia, and one side of the ethmoid sinus was randomly selected to implant a fully degraded sinus drug stent. The patients were followed up for 3 months after the operation. The Visual Analogue Scale (VAS) score for nasal symptoms and the Lund-Kennedy score of nasal endoscopy were evaluated before operation and at 2,4,8 and 12 weeks after operation. Results In the VAS score of nasal symptoms in the two groups, there were significant differences in the nasal congestion scores at 4,8 and 12 weeks after operation, P<0.05 and in runny nose score at 2,8 and 12 weeks after operation (P<0.05). There were significant differences in olfactory and head swelling scores at 4 and 8 weeks after operation (P<0.05). In the Lund-Kennedy score of nasal endoscopy, there were significant differences in polyps and edema scores between the two groups at 8 and 12 weeks after operation (P<0.05), and in rhinorrhea score at 2,8 and 12 weeks after operation (P<0.05). There were significant differences in scab score at 4,8 and 12 weeks after operation (P<0.05). Conclusion It is safe and reliable for patients with CRSwNP implanted with fully degraded sinus drug stents at 2 weeks after surgery, who have better clinical efficacy than that during surgery.