Objective: To investigate the clinical efficacy and safety of implanting fully degraded sinus drug stents in patients with chronic sinusitis and nasal polyps 2 weeks after functional endoscopic sinus surgery. Methods: A total of 50 patients diagnosed in the Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of North Sichuan Medical College were randomly divided into intraoperative implantation group and postoperative implantation group, with 25 cases in each group. Patients in both groups underwent endoscopic all sinuses surgery and nasal polypectomy. The intraoperative implantation group was used as the control group. During the same period, one side of the ethmoid sinus was randomly selected to implant a fully degraded sinus drug stent. The postoperative implantation group was used as the experimental group. Two weeks after endoscopic sinus surgery, the nasal cavity was cleaned by nasal endoscopy under local anesthesia and one side of the ethmoid sinus was randomly selected to implant a fully degraded sinus drug stent. The patients were followed up for 3 months. The VAS score of nasal symptoms and Lund-Kennedy score of nasal endoscopy were performed before operation and 2,4,8 and 12 weeks after operation. Results: In the VAS score of nasal symptoms in the two groups, the nasal congestion score was significantly different at 4,8 and 12 weeks after operation, P < 0.05 ; there were significant differences in runny nose score at 2,8 and 12 weeks after operation ( P < 0.05 ). There were significant differences in olfactory and head swelling scores at 4 and 8 weeks after operation ( P< 0.05 ). In the Lund-Kennedy score of nasal endoscopy, there were significant differences in polyps and edema scores between the two groups at 8 and 12 weeks after operation (P< 0.05). There were significant differences in rhinorrhea score at 2,8 and 12 weeks after operation ( P< 0.05 ). There were significant differences in scab score at 4,8 and 12 weeks after operation ( P< 0.05 ). Conclusion: Patients with chronic sinusitis and nasal polyps implanted with fully degraded sinus drug stents at 2 weeks after surgery have better clinical efficacy than simultaneous implantation during surgery, and are safe and reliable.